Is a slow-acting drug taken as a pill that may slow the breakdown of cartilage and relieve pain and swelling.The review searched for studies up to March 2013 about primary osteoarthritis affecting men and women (18 years and older) of any disease severity.
Glucosamine is marketed to support the structure and function of joints and the marketing is targeted to people suffering from osteoarthritis. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, some have hoped that supplemental glucosamine could beneficially influence cartilage structure, and alleviate arthritis. Its use as a therapy for osteoarthritis appears safe. but there is no unequivocal evidence for its effectiveness. There have been multiple clinical trials testing glucosamine as a potential medical therapy for osteoarthritis, but the results have not supported its use.
In general, the clinical trials of the mid-1990s that furnished positive results showing glucosamine efficacy were later deemed to be of poor quality due to shortcomings in their methods, including small size, short duration, poor analysis of drop-outs, and unclear procedures for blinding. At the same time, several independent studies did not detect any benefit of glucosamine supplementation on osteoarthritis.
MSM is used for chronic pain, osteoarthritis, joint inflammation, rheumatoid arthritis,osteoporosis, bursitis, tendonitis, tenosynovitis, musculoskeletal pain, muscle cramps, scleroderma, scar tissue, stretch marks, hair loss, wrinkles, protection against sun/wind burn, eye inflammation, oral hygiene, periodontal disease, wounds, cuts, and abrasions/accelerated wound healing. It is either taken by mouth or applied to the skin for these uses.